Published in Biochemical Pharmacology and by researchers at University of Texas Medical Branch
Fatigue Some individuals feel tired due to appetite suppression and lower calorie intake
Injections are particularly appropriate for those with: Pernicious anaemia, an autoimmune condition affecting B12 absorption Conditions affecting the stomach or small intestine, such as Crohns disease or coeliac disease Those who have had gastric surgery or bariatric procedures Strict vegans and vegetarians not meeting their B12 needs through food or oral supplements For those who can absorb B12 normally, oral supplements are generally an effective and well-evidenced alternative to injections
Here's a slightly different approach to the question: While we don't expect B12 to 'give' us energy, is it worth taking vitamin B12 dietary supplements or multivitamins containing B12
The fact that many people use these products without visible harm does not mean the risks are negligible
These rare allergic reactions can include itching or rash, fever, swollen tongue, and other symptoms (Vassavada, 2021