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Similar content being viewed by others Introduction As clinicians, healthcare systems, and the pharmaceutical industry try to move away from generic disease management towards precision medicine, several fundamental issues need to be addressed in order to maximize therapeutic efficacy and minimize adverse events 1

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[40] Kasperczyk, S., Dobrakowski, M., Kasperczyk, A., Romuk, E., Rykaczewska-Czerwiska, M., Pawlas, N

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When considering study drug discontinuation or use of rescue medication (trial product estimand results), the weight loss resulting from the use of oral semaglutide was up to 5 kg, while that associated with other active comparators ranged from 0.8 to 3.8 kg, and that associated with placebo ranged from 0.1 to + 0.6 kg [35,36,37,38,39,40]

NREM2, non rapid eye movement sleep phase 2