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iris.who.int/bitstream/handle/10665/43190/9241593024_eng.pdf (2005)

Research has demonstrated that roasting can reduce histamine levels in coffee by approximately 3050% compared to green bean baseline, with darker roasts showing greater reduction than lighter roasts due to extended heat exposure [ 2 ]

Struyfs, C., Cammue, B., and Thevissen, K., Front

As we stated in the proposed rule, requiring the median rather than the average is consistent with generally accepted statistical principles for assessing the central point of a distribution when there are outliers

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This matters because your body naturally makes less collagen as you age and the collagen you have left breaks down faster, so supporting that process directly is more useful than masking the surface