GLP-1 receptor agonists mimic a naturally occurring gut hormone called glucagon-like peptide-1 (GLP-1), which slows how quickly food moves from your stomach into your small intestine
Over time, the tirzepatide molecule breaks down, meaning you might not receive the full doses benefit, potentially leading to increased hunger or slower weight loss
Yet even a DPP-4-resistant peptide is small enough to be filtered by the glomeruli in the kidneys into the urine
Physical function improved too
Male-pattern hair loss (androgenic alopecia) is already common and may accelerate during GLP-1 therapy due to shifting androgen metabolism
Back Barany, G, Barany, MJ (27 Sept 2024) 'Foundational contributions of Svetlana Mojsov to the GLP-1 field', Explorations of Drug Science , 2, 688700