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Second-generation: cilofexor (GS-9674), tropifexor (LJN452) Cilofexor is a potent, selective, nonsteroidal agonist of FXR that predominantly activates intestinal FXR without involvement of the enterohepatic circulation

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/GIPR/GLP1R [3] GCGR 29GCGRG(GPCR)GCGRGLP1RGCGRGLP1RGGscAMPGLUT2ATPcAMPPKA [4] 3

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