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This medical condition causes discomfort and can compromise the effects of diabetes treatment

Specifically, DPP-4 cleaves the peptide bond between Ala 8 -Glu 9 resulting in the abundant GLP-1 (936) amide constituting 6080% of total GLP-1 in circulation

Additionally, decreased intestinal cholesterol absorption in patients with insulin resistance and obesity may limit increases in LDL-C levels [15]

At baseline, 74% patients were classified as NYHA class II, 26% class III and 0.4% class IV, 35% of the patients had LVEF 49%, 36% had LVEF 50-59% and 29% had LVEF 60%

Another significant effect of semaglutide is delayed gastric emptying