Disease, medication, professional obligations (e.g., shift workers), or unhealthy lifestyle (e.g., irregular sleep and feeding rhythms) have been shown to strongly affect circadian rhythms in peripheral tissues
Roy SJ, Gilliham M, Berger B, Essah PA, Cheffings C, Miller AJ, Davenport RJ, Liu LH, Skynner MJ, Davies JM (2008) Investigating glutamate receptor-like gene co-expression in Arabidopsis thaliana
If you plan to study the pairing, start with that protocol page for the documented blend numbers rather than improvising a combination
doi: 10.1016/j.immuni.2015.06.010
Others space it out to every few weeks or monthly
Obtain a new, unexpired supply of medication and resume treatment with the fresh supply as advised by your doctor