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Moreover, in addition to the direct action of GIP in adipose tissue to reduce serum triglyceride levels, GLP-1 may abolish the postprandial rise in triglyceride and free fatty acid concentrations by reducing intestinal absorption of dietary lipid, stemmed from the delayed gastric emptying (197, 198)

and have not been demonstrated to the FDA to be safe or effective for their intended use

Dosing protocols Phase 2 clinical trials used a titration schedule starting at 0.5mg weekly, escalating through 1mg, 2mg, 4mg, 8mg, and reaching maintenance doses of up to 12mg weekly over several months

All GLP-1 drugs have similar side effects

Once reconstituted, refrigerate and use within 20 days

We asked the Anesthesia Manual App: Should GLP-1R agonists be stopped preoperatively?