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Permanent discontinuation of treatment as a result of a gastrointestinal adverse reaction occurred in 4.3% of WEGOVY-treated adult patients versus 0.7% of placebo-treated patients

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Semaglutide commonly causes nausea, constipation, and mild stomach discomfort, especially early on

The dropout rate, which the cultural narrative tends to elide, is significant, somewhere between 10% and 25% of patients discontinue within the first year, the majority due to gastrointestinal side effects that for some are tolerable nuisance and for others are quality-of-life-destroying

doi: 10.3389/fmolb.2019.00116 42

Dense GLP-1R immunostaining, mostly consisting of perikarya and dendrites, was observed in the sacral dorsal commissural nucleus (Fig