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Periodic boundary conditions were used with a cutoff of 10 for non-bonded interactions and the Particle Mesh Ewald method for long-range electrostatics

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Utilisation Adultes : Carence en vitamine B12 sans complication clinique (par exemple anmie pernicieuse et malabsorption) Par injection : Voie orale : Dose initiale : administrer 1 ampoule (1mg) par jour ou 3 ampoules par semaine, renouveler en fonction des rsultats hmatologiques