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Since oxidative stress and inflammation are closely associated with insulin resistance, it is conceivable that the AGE-RAGE system may play a role in pathogenesis of insulin resistance observed in PCOS [30], regardless of circulating glucose levels, weight and obesity

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Insulin also decreases gluconeogenesis (synthesis of glucose from noncarbohydrate carbon substrates) and glycogenolysis (breakdown of glycogen)

Those who with neuropathy present with a warm, swollen, red foot requires a thorough work up for possible charcot neuroarthropathy, nonweight bearing and urgent referral to a foot care specialist to prevent foot deformities and instability leading to ulcerations and amputations