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R 3 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl-OR S , optionally substituted C 1 -C 6 alkylC 3 -C 6 cycloalkyl, optionally substituted C 2 -C 7 heterocycloalkyl, C 1 -C 6 alkyl-CO 2 R 6 , C 1 -C 6 alkyl-C(O)NR 5 R 6 , or R 2 and R 3 together with the nitrogen to which they are attached form an optionally substituted C 2 -C 7 heterocycloalkyl ring

doi: 10.1016/j.lfs.2020.117996 4 ScheltensPDe StrooperBKivipeltoMHolstegeHChtelatGTeunissenCEet al

Evidence suggests that excessive adiposity contributes to increased airway resistance and reduced responsiveness to corticosteroid therapy and short-acting 2AR agonists [19, 27, 31, 40]

Clinically, gonadorelin is used to diagnose and treat some forms of male infertility and functional hypogonadism

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PMID 10970056