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Human trials need to define the product, route, dose, comparator, outcomes, adverse-event collection, and follow-up before those claims can be tested reliably

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In a Swiss study (11), almost half of all general practitioners agreed with prescribing B12 for unexplained fatigue, even though theres not much research to bear it out

J Comp Neurol 505:158165 Rosado JO, Salvador M, Bonatto D (2007) Importance of the trans-sulfuration pathway in cancer prevention and promotion