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Because they utilize completely separate mechanisms (angiogenesis vs

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The increment in intestinal permeability is another prominent mechanism in the gut-brain axis communication in patients with migraine, leading to inflammation and the release of pro-inflammatory cytokines (200, 201)

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In addition, pegilodecakin, a long-acting recombinant pegylated IL-10, has been evaluated in dose escalation/expansion study in patients with advanced solid tumors as a monotherapy or combination with other anticancer drugs in a phase I trial (NCT02009449)