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This is a twenty-year perspective of how dual incretin agonists have evolved, culminating in the clinical use of tirzepatide, along with a discussion of potential mechanisms by which GIPR agonism can enhance the clinical efficacy of GLP-1R agonists

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222,240 Overall, p53 activation increases the expression of -synuclein or parkin, which subsequently decreases p53 levels and parkin and -synuclein transcription to reach equilibrium

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