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When GLP-1 treatments hit the market in the early 2000s, Breakthrough T1D and others funded several clinical trials to test whether GLP-1 receptor agonists, in addition to insulin, improved outcomes for people with type 1 diabetes

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Semaglutide led to a significant reduction in HbA1c levels compared to placebo- Patients receiving semaglutide experienced significant weight loss compared to those on placebo PIONEER Trials (Peptide Innovation for Early Diabetes Treatment): The PIONEER (Peptide Innovation for Early Diabetes Treatment) trials were a series of global, randomized, controlled clinical trials that investigated the efficacy, safety, and tolerability of oral semaglutide, a GLP-1 receptor agonist, in patients with type 2 diabetes