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Importantly, along with an induction of HIF1, in SCD erythroblasts cultured in the absence of hemin, we detected a significantly decreased CBS expression under hypoxia compared to normoxia (Supplementary Fig

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The cardiovascular system is uniquely vulnerable to ferroptotic stress due to its high metabolic demand, elevated oxygen consumption, and dense mitochondrial networks, which together generate substantial reactive oxygen species (ROS)

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Notably, pro-inflammatory genes such as Il13, Il5, Csf2 among others were consistently downregulated following melatonin treatment ( Figure 5C )