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This study demonstrated that breast cancer brain metastases enhance gluconeogenesis and utilize glutamine and leucine to sustain purine synthesis under glucose limitation, with FBP silencing reducing metastasis

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Enhanced Molecular Target Coverage Combined treatment protocols demonstrate additive effects on multiple enzymatic pathways, including matrix metalloproteinase expression and activity

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Relevant to this, the efficacy of inhibitors directed against several lipogenic enzymes (including fatty acid synthase) was reviewed in refs