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Several of the DEGs were TF genes, including Klf4 and Klf5 , (Extended Data Fig

It features a heterodifunctional molecule integrating two crucial ligands: one targeting and binding to the protein of interest, and another engaging with an E3 ligase, a pivotal element within the ubiquitin-proteasome system tasked with marking proteins for degradation (Zeng et al., 2021)

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Sci Rep 8:10056 Nasca C, Xenos D, Barone Y, Caruso A, Scaccianoce S, Matrisciano F, Battaglia G, Math AA, Pittaluga A, Lionetto L, Simmaco M, Nicoletti F (2013) L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of MGLU2 receptors