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Intravenous glutathione, although having rapid action, is associated with serious safety concerns like anaphylaxis and hepatotoxicity, further aggravated by a lack of standardized dosing protocols.The adverse effects caused by intravenous glutathione have led the Food and Drug Administration of Philippines to issue a public warning condemning its use for off-label indications such as skin lightening

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Skin and Dermatological Symptoms Unexplained rashes, hives, or heightened skin sensitivity are also common, particularly in patients with significant immune dysregulation