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Este fenmeno se ve acentuado por el tabaquismo, la contaminacin, la exposicin a los rayos UV o las radiaciones ionizantes, el consumo de alimentos fritos o cocinados a altas temperaturas o la prctica de una actividad fsica intensa (12)

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128 These findings demonstrate that glucagon activity regulates the proportion of the different endocrine cell types in islets, the number of islets in the pancreas, and the development of the mature alpha-cell phenotype

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