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Wegovy has the cardiovascular benefit label the NICE April 2026 cardiovascular indication (BMI 27+ with established CVD) applies to semaglutide (Wegovy), not tirzepatide (Mounjaro)

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It is derived from a naturally occurring protein called Body Protection Compound (BPC), which is found in human gastric juice

It belongs to a class of drugs known as multi-receptor agonists, and its mechanism of action is notably broad: it simultaneously activates three hormone receptors the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor

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TRIUMPH-4 (December 2025) TRIUMPH-1 (May 21, 2026) The consistency between TRIUMPH-4 (28.7%) and TRIUMPH-1 (28.3%) in different populations, different durations is exactly what the FDA looks for in a robust efficacy package