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Data from the SURMOUNT trials showed that participants losing significant weight on tirzepatide experienced approximately 33-39% of total weight loss from lean body mass

The content of reduced glutathione in muscles and blood serum decreased, probably, due to its utilization for ROS neutralization

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35,36 The production of ATP in the mitochondria and the maintenance of the membrane potential require NAD + as a universal cofactor

Within thyroid follicles, newly synthesized TG is transported along the secretory route to the apical plasma membrane of thyroid epithelial cells

Synaptic adhesion molecules are associated with changes in synaptic plasticity, and it remains to be seen whether neurexins, as the core of the transsynaptic complex, are redistributed either by themselves or by synaptic adhesion molecules to which they bind, and once the mechanism of redistribution is clarified, it will be of great interest to further link with sustained antidepressant effect