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These findings are aligned with prior research, including the randomized study by Kahal et al

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Our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in TMX-treated rats

Pharmacology 61 , 154166 (2000)

The clinical use of Dihexa in wellness and longevity settings is based on the preclinical evidence combined with growing clinical observation from providers who prescribe it off-label