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This is a very important point it seems that children with folate receptor autoantibodies are the most likely to respond to folinic acid in these instances

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Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, et al

PYY can improve intrinsic defects in the intestinal epithelium of clinical colitis specimens Organoid cultures were derived from nineteen colon mucosal biopsies of CD patients undergoing routine follow-up, with a few being newly diagnosed patients (Supplementary Table 1)