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Clin Cancer Res 24(16):3867-3877, 2018

Maintenance treatments can help sustain benefits over time

However, drastic redistributions of MDM2 from p53 to the IGF-1R can probably only be achieved after experimental modulations, like inhibition of p53 expression by antisense strategies, etc, and do not likely occur in this manner in a physiologic context

doi: 10.1016/j.amjmed.2023.07.016 [DOI] [PubMed] [Google Scholar] 176.United State Food and Drug Administration

"Until we have better evidence, people taking GLP-1RAs should be carefully monitored, especially those with mental illness." Beneficial impact on mental health The analysis also found that GLP-1RAs had a beneficial effect on mental health in adults with and without mental disorders

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