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55 Therefore, the anatomy and a functional role of the vagus nerve in relation to adipose tissue is an area of active study

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Tirzepatide, the active ingredient in Zepbound and Mounjaro, targets both GLP-1 and GIP receptors, two hormone pathways involved in appetite and metabolic regulation

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The decision depends on individual anatomy, skin quality, and desired outcomes assessed during consultation

In a systematic review of 10 clinical trials in patients with HIV lipodystrophy, tesamorelin was effective in reducing VAT and increasing lean body mass and did not alter subcutaneous adipose tissue (146), and increased GH and IGF-I while insulin and glucose levels are unchanged indicating preservation of insulin sensitivity (147150) ( Table 1 )