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Intravenous (IV) or Intramuscular (IM) injection

These chronic attributes are generally associated with selective degeneration of dopaminergic neurons, corollary de-pigmentation of substantia nigra pars compacta (SNpc) and concomitant accumulation of -synuclein in insoluble inclusions called Lewy bodies 2,3

Ginsberg, J

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Substrate binding of c-Jun induces dimeric DDD-Ube2e2-COP1 formation Since we hypothesized that the purified stacked DDD-Ube2e2-COP1 protein assemblies might represent inactive states, we next sought to investigate how c-Jun is recognized by the CULLIN4 DET1-COP1 E3 ligase