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In contrast, the JmJC domain-containing demethylases, belonging to the 2-oxoglutarate-dependent dioxygenases, are capable of removal of trimethylations

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[3] [16] For conditions where inflammation plays a central role such as type 2 diabetes, cardiovascular disease, or MASLD NICE guidance focuses on managing the underlying metabolic risk factors rather than targeting inflammation directly

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Potentially yes

These patients are at greater risk of adverse cardiovascular events compared to those with CAD alone [25]