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Bile acids , secreted from the gallbladder upon eating, robustly activate a series of metabolic hormones including GLP-1 (Zietek, et al., 2018)

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That excess thyroid hormone dramatically increases your metabolism, or how many calories your body needs to maintain your weight, meaning you often lose weight despite eating more than usual, says Kaniksha Desai, MD, an endocrinologist at Stanford Medicine in California

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Retatrutide is known as a triple agonist