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Testing for Vitamin B12 Levels Lab tests to assess vitamin B12 status are not as straightforward as other nutrients

Redundancy and hierarchical complexity can complicate interpretation, especially when multiple related terms appear significant, and annotation coverage varies across organisms and data types, with non-model species often exhibiting limited GO representation

N Engl J Med 316:971977

In patients with idiopathic PAH, the expression of PD-1/PD-L1 on the surface of peripheral blood CD4 + and CD8 + lymphocytes are significantly upregulated, the proportion of Tregs is increased, and IL-10 secretion is reduced, suggesting that excessive activation of the PD-1/PD-L1 axis synergizes with Treg dysfunction to exacerbate immune dysregulation and affect metabolic homeostasis (Tomaszewski et al., 2024)

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