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VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1

Interventions: Cagrilintide, semaglutide, placebo Primary Outcome Measures: Relative change in body weight

If side effects at a new dose level are severe and do not improve after 4 weeks, your provider may recommend reducing back to the previous dose

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Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

Binding to GHSR-1a stimulates GH release via a calcium-dependent, cAMP-independent intracellular pathway, distinct from GHRH-mediated signalling