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This is achieved by two engineering tricks: non-proteinogenic (non-natural) amino-acid substitutions near the N-terminus that sterically block the enzyme, and acylation with a fatty diacid that gives reversible binding to plasma albumin and dramatically extends circulation time

Polymorphonuclear leukocyte chemotaxis induced by zinc, copper and nickel in vitro

It has been verified that the levels of BAs may be associated with visceral pain and colonic transit (Sayin et al., 2013)

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A novel case report described successful triple therapy for an infant with rapidly progressive infantile-onset LAL-D diagnosed antenatally (49)