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Discontinuing GLP-1s may result in the return of appetite and weight gain

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This model is also satisfying from an evolutionary biology perspective in which GLP-1 and GIP do not have redundant functions in the brain, but rather fit into complimentary niches

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Obesity coverage by US payors should increase as prices fall, but in many European countries, particularly Germany, France and Spain, the issue lies with obesity being regarded as a lifestyle disease, and so something that should not be treated with drugs

One promising solution is to pair GLP-1 therapies with agents that block negative muscle regulators like activin receptor type II (ActRII) and ligands such as GDF8 (myostatin) and activin A