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Animal studies demonstrate localized anabolic signaling rather than widespread systemic IGF-1 elevation

PMID: 31336737

Hypertension is a major risk factor for CVD

For the first primary endpoint, 62.9% of participants treated with semaglutide achieved resolution of steatohepatitis, with no worsening of liver fibrosis, compared to 34.1% on placebo (estimated difference in responder proportions [EDP] of 28.7%

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