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Especially in PDLSC, Ex-4 has also proven to activate MAPK and WNT-signaling [19, 21, 24] as well as Hedgehog/Gli1-1 and nuclear factor kappa B (NF-B) signaling, thus promoting osteogenic differentiation [15, 17, 21, 24, 26, 38]

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Fixed-effect meta-analysis and multi-ancestry GWAS We conducted a fixed-effect meta-analysis across three ancestry groups (European, African, and Admixed American/Latino) by integrating summary statistics from separate GWAS for each group