Metabolically constrained, potentially reversible dysfunction may be more amenable to strategies that restore mitochondrial fitness (e.g., redox modulation) and support lymphocyte recovery (e.g., IL-7/IL-15), whereas exhaustion-like states may require checkpoint modulation in combination with approaches that target upstream mitochondrial stress and the TOX/NR4Aepigenetic axis
The role of myelin and oligodendrocytes in axonal energy metabolism
It may be used as a diagnostic measure to identify the cause of the fluid accumulation, for example, infection, gout, or rheumatoid arthritis, or as a therapeutic intervention to relieve pressure and discomfort
and broad transcriptional effects, with gene-expression analyses identifying modulation of expression patterns associated with antioxidant defense, DNA repair, and tissue remodeling
Hussein NH, Gado OM, Fouad AA, Khalil YA
doi: 10.1016/j.bbalip.2012.10.007