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PMID: 28811802

Discussing a targeted clinical review including thyroid function, a medication review, and screening for OSA where appropriate with your GP is advisable in such circumstances

We are moving from a willpower mindset to recognising weight as a chronic biological condition that can be managed, much like asthma or hypertension, with effective medical treatment

Supporting a diverse, healthy microbiome through prebiotic and probiotic-rich foods may therefore indirectly enhance GLP-1 activity, though evidence is still emerging

Unexpected pregnancies on tirzepatide have been reported, often attributed to improved fertility from weight loss

(2) Sarin exerts toxicity by irreversibly inhibiting acetylcholinesterase (AChE), resulting in accumulation of acetylcholine at cholinergic synapses and subsequent neuromuscular and respiratory dysfunction