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What the data clearly support is that 4 mg was an effective destination in its own right: nearly 20% average weight loss, only one escalation step after the 2 mg starting dose and a 4.1% adverse-event discontinuation rate

J Clin Endocrinol Metab 2005

However, the nature of optimal dietary support may differ between the two compounds

8 Based on data from the MAESTRO-NASH trial, resmetirom demonstrated histological benefits with a number needed to treat of five for the resolution of MASH and 8.5 for fibrosis regression, 9 thus posing significant economic challenges

It has shown promising results in clinical trials, helping people achieve substantial weight loss

Theyre effective for many men, but heres the catch: they dont address why the