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These peptides may also strengthen the skin barrier by increasing structural proteins such as filaggrin and involucrin

doi: 10.3390/pharmaceutics13060911 202 KorbeckiJBosiackiMKupnickaPBarczakKZietekPChlubekDet al

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[DOI] [PubMed] [Google Scholar] 109.Irwin N., McClean P.L., Cassidy R.S., Oharte F.P., Green B.D., Gault V.A., Harriott P., Flatt P.R

This of course should not be taken to mean that overdoses arent frequent in rural areas and rural areas arent adversely impacted by the current overdose crisis