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Continuous, uninterrupted use past 8 weeks doesn't accelerate healing further

This makes it easier to ensure your B12 gets right into the muscle and not into the fat or lost somewhere in between

The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

If there is too much, it turns TSH down

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If the ODT works for you at 5 mg but you would benefit from 7.5 mg or more, you have no oral option for escalation and would need to switch to injection