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In breast cancer cells, AGR2 expression decreases the degradation of HIF-1 and increases MDR1 transcription, thus decreasing epirubicin uptake and promoting doxorubicin ( DOX ) resistance in breast cancer cells 42

BPC-157 is legal when prescribed by a licensed provider and obtained through a compounding pharmacy

For experimental designs that need both axes covered in parallel, see our full BPC-157 + TB-500 dosing protocol and the BPC-157 vs TB-500: how the two peptides compare guide

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Critics, including the FDA's own scientific staff, argue that insufficient evidence exists to ensure these compounds are safe for human use