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Additionally, occludin and ZO-1 mRNA levels (Figures 3B,C) in the FC group were nearly half of those in the CON group but significantly increased after BDF intervention

Metabolic comorbidities are highly prevalent and bidirectionally linked to MASLD: type 2 diabetes, hypertension, dyslipidemia, and chronic kidney disease (CKD) cluster together, collectively amplifying hepatic and systemic disease progression