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A similar rationale underpins regimens for Friedreichs ataxia, where riboflavin plus antioxidants (CoQ10, -lipoic acid) counter mitochondrial ironsulfur-cluster loss and free-radical injury, offering symptom relief beyond monotherapy (79, 80)

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J Enzyme Inhib Med Chem 24:395405 [DOI] [PubMed] [Google Scholar] Koksal E, Bursal E, Dikici E, Tozolu F, Gulcin I (2011) Antioxidant activity of Melissa officinalis leaves