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Plateaus are a normal part of the process and often resolve with dietary adjustments, increased physical activity, or a prescriber-supervised dose modification

[41] [42] Functional vitamin B 12 deficiency can also develop with heavy regular use of nitrous oxide N 2 O, also known as "laughing gas", by oxidizing the cobalt atom and inactivating the vitamin

The benefits are felt almost immediately and typically last 57 days

Peer-reviewed and received in revised form 11 January 2022

For individuals with minimal subcutaneous tissue, discussing injection technique with a provider can reduce discomfort significantly

However, subcutaneous injection is the standard route for systemic and musculoskeletal effects, as it provides more reliable bioavailability and allows injection near the injury site