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BPC-157 has been around for decades, but only recently has it gained widespread attention in sports medicine, biohacking, and longevity circles

They concluded that exercise is a well-established, evidence-based treatment for knee OA, making further trials against minimal treatment unnecessary (Verhagen et al., 2019)

However, Semaglutide is a long-acting medication

Preclinical signals regarding potential effects on thyroid C-cells (observed with GLP-1 agonists as a class), as well as theoretical questions about bone metabolism and cardiovascular function, are being monitored in ongoing trials

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Some substitutes have also been linked to an elevated risk of heart disease and other conditions