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Since ADA (American Diabetes Association) and FDA confirmed that apart from metformin in Type 2 diabetes management, Glucagon-like peptide-1 analogues give favourable results, especially in contraindication and metformin intolerance patients, so the use of GLP-1 agonists is highly preferred treatment in lower serum glucose levels or hypoglycemia

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Combination therapy (ixekizumab + tirzepatide) showed a clear advantage, with nearly one-third of patients achieving the primary endpoint compared to less than 1% with ixekizumab alone

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