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The inflammatory milieu subsequently drives hepatic stellate cell activation and transdifferentiation into myofibroblasts, leading to excessive extracellular matrix deposition and progressive fibrosis, which represents the primary determinant of long-term liver-related outcomes [17]

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The introduction of tirzepatide, the first dual agonist targeting both the GLP-1R and the glucose-dependent insulinotropic polypeptide (GIP) receptor, represents a new frontier in incretin-based therapy (Syed, 2022

[12] [13] 4 mg (Wegovy)

Researchers who experienced significant gastrointestinal side effects, particularly nausea and vomiting in the first 24 to 48 hours after injection, began experimenting with split doses to smooth out the concentration curve