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PMID: 37 ThomasRLJiangLAdamsJSXuZZShenJJanssenSet al

The structure showed the FERM domain has a canonical three-lobe structure (F1F3), and the SH2 has a preserved SH2-like structure despite lacking the highly conserved arginine residue in the phosphotyrosine binding site (71, 72)

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Both are active areas of clinical research, and the responsible position is to treat them as supervised wellness therapies rather than guaranteed cures

Furthermore, inflammation in the gut has been linked to an increase in circulating pro-inflammatory cytokines, which are known to contribute to kidney damage and fibrosis (Lau et al., 2015)