IL-1 then activates pyroptosis by binding to its receptor on the cell membrane, resulting in the formation of gasdermin D (GSDMD) pores that cause cell membrane rupture and the release of proinflammatory cytokines and damage-associated molecular patterns (DAMPs), such as high-mobility group box 1, heat shock proteins, and fibronectin advanced glycation end-products IL-33
The most common side effects include gastrointestinal issues such as nausea, diarrhea, and constipation
(eds) The Heterogeneity of Cancer Metabolism
Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on October 24th, 2025
10.1016/j.jinf.2024.106379 J Infect
Oliveira, J., Pieniz, S.: Curcumin in Alzheimers disease and depression: therapeutic potential and mechanisms of action